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RNA aptamer (2′-O-methyl, cholesterol-conjugated) [ligand; not therapeutic payload]

Linked experiment: EXP001954

Linked peptide: D-arm/R8-modified MITO-Porter (2.5 mol% Chol-D-arm)

Linked paper: A Dual-Ligand Liposomal System Composed of a Cell-Penetrating Peptide and a Mitochondrial RNA Aptamer Synergistically Facilitates Cellular Uptake and Mitochondrial Targeting (2016)

RNA fields

RNA Type

RNA aptamer (2′-O-methyl, cholesterol-conjugated) [ligand; not therapeutic payload]

RNA Payload Or Target

Mitochondrial targeting (RP/MRP/D-arm aptamer as targeting ligand); no gene-silencing payload delivered

RNA Modifications

5′-GGGACUGUAGCUCAAUUGGUAGAGCAU-3′ (2′-O-methyl RNA; Cholesterol at 3′ end)