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siRNA (duplex, 21-mer with 3′ TT overhangs)

Linked experiment: EXP002002

Linked peptide: Cholesterol-DP7-ACP-T7 (DAT) (dual-functional peptide on liposome)

Linked paper: A blood–brain barrier- and blood–brain tumor barrier-penetrating siRNA delivery system targeting gliomas for brain tumor immunotherapy (2024)

RNA fields

RNA Type

siRNA (duplex, 21-mer with 3′ TT overhangs)

RNA Payload Or Target

slit2 (si slit2) knockdown in glioma (GL261); targets migration/invasion and modulates immune microenvironment

RNA Modifications

Sense: 5′-GCCACGGGAAUAUUUAAGATT-3′; Antisense: 5′-UCUUAAAUAUUCCCGUGGCTT-3′. NC siRNA also used.