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A blood–brain barrier- and blood–brain tumor barrier-penetrating siRNA delivery system targeting gliomas for brain tumor immunotherapy

Paper ID

PAPER000334

Year

2024

DOI

10.1016/j.jconrel.2024.04.006

PMID

38575072

Journal

Journal of Controlled Release

Source URL

Experiments

• EXP002001 with Cholesterol-DP7-ACP-T7 (DAT) (dual-functional peptide on liposome) (siRNA (duplex, 21-mer with 3′ TT overhangs))
• EXP002002 with Cholesterol-DP7-ACP-T7 (DAT) (dual-functional peptide on liposome) (siRNA (duplex, 21-mer with 3′ TT overhangs))
• EXP002003 with Cholesterol-DP7-ACP-T7 (DAT) peptide (siRNA (Cy5-labeled for biodistribution imaging))
• EXP002004 with Cholesterol-DP7-PEG2-T7 peptide (siRNA (Cy5-labeled for biodistribution imaging))
• EXP002005 with Cholesterol-DP7-Gly6-T7 peptide (siRNA (Cy5-labeled for biodistribution imaging))
• EXP002006 with Cholesterol-T7-ACP-DP7 peptide (siRNA (Cy5-labeled for biodistribution imaging))
• EXP002007 with Cholesterol-T7-PEG2-DP7 peptide (siRNA (Cy5-labeled for biodistribution imaging))
• EXP002008 with Cholesterol-T7-Gly6-DP7 peptide (siRNA (Cy5-labeled for biodistribution imaging))
• EXP002009 with Cholesterol-DP7-T7 peptide (siRNA (Cy5-labeled for biodistribution imaging))